Description
Product Characteristics: BARK1, GRK2, ADRBK1, adrenergic, beta, receptor kinase 1, BETA-ARK1, beta adrenergic receptor kinase 1
Target Information: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]